Technical track
For working analytical chemists
Date and price TBA
3 hours · Toronto time
Coming soon
LC-MS and HPLC method troubleshooting: a systematic framework
Date and price to be announced · 3 hours · Toronto time
The problem
Most method development training stops at the textbook. The real bottlenecks are in the decisions you make when the data doesn't behave: when do you change the column, when do you adjust the gradient, and when do you start over?
What you'll learn
- You'll be able to diagnose LC-MS and HPLC problems in the right order, not the obvious one
- You'll understand how to defend method development decisions to managers and auditors
- You'll know when to validate versus verify on method transfer
- You'll get the troubleshooting framework from 14 years of bench experience
Who this is for
- QC analysts and method development chemists with 2+ years at the bench
- Chemists responsible for method validation who want a clearer decision framework
- Lab leads who need to explain method choices to auditors and managers
Who this is NOT for
- Students or early-career chemists not yet working with methods in an industry context (see the career-bridge track)
- Anyone looking for a regulatory or compliance course — this is bench-first, not audit-first
Questions
- Is this specific to a particular industry?
- The troubleshooting framework applies across industries. Examples draw from pharma, environmental, and natural-product work, but the logic transfers to any reversed-phase LC work.
- What instrument brands does this assume?
- None. The framework is instrument-agnostic. Where specific instruments are referenced, it's for illustration only.
- Will there be hands-on exercises?
- Yes. We'll work through real case studies with actual data. You'll apply the framework during the session, not just hear about it.
About the instructor
Pawliszyn-trained Ph.D. analytical chemist. 14 years across pharma, CRO, environmental, and natural-product labs. I've developed and validated LC-MS and HPLC methods, trained 200+ scientists, and published 18 peer-reviewed papers. I teach what actually happens at the bench.
More about me