HPLC · 10 min read
What an HPLC system suitability failure is telling you
A tailing factor of 1.9 against a limit of 2.0 is a passing test and a failing column. How to read what an SST shows you before it fails.
Read the essayJune 23, 2026
— 01
Online for the fundamentals, or hands-on: at my bench, or in your lab on your own instruments. Method development and troubleshooting for companies, where the cause is usually in the sample preparation and that is the last place a lab checks. My PhD was in the lab that invented SPME.
200+ scientists trained. 18 peer-reviewed papers, 1,900+ citations. 14 years across pharma, CRO, environmental and natural product labs.
A two minute introduction
Who I am, what I actually do in a lab, and when it is worth calling someone in.
— 02 / Who is this for
For labs that run an HPLC or LC-MS
On-site and remote help for labs that run an HPLC or LC-MS without a chromatographer on staff. I find the cause, and I train whoever runs the instrument.
See how I work →
A chemistry postdoc or recent graduate moving into industry? The workshops and CV workbook are over here.
— 03 / What I do
Start here
Hands-on training on your own instruments, for whoever runs them. Sample preparation, HPLC and LC-MS, so they can do the same diagnosis.
See trainingA method that has failed and already been worked on. I find the cause, and it is usually upstream of the instrument.
See consultingMonitoring, calibration records, reagent stock and the audit trail. Independent help deciding what you need before anyone sells you a platform.
See lab operationsTechnical workshops on method development and troubleshooting for working chemists. A separate career track runs for people moving into industry.
View workshops— 04 / Start free
Written for the bench, not for a mailing list. Take them, use them, and come back if the problem is still there.
The order I check things in when sensitivity drops or a peak misbehaves.
Get it →What has to be true before you start a validation, so it does not stall halfway.
Get it →For anyone moving from academic work into an industry lab.
Get it →— 05 / From the writing
HPLC · 10 min read
A tailing factor of 1.9 against a limit of 2.0 is a passing test and a failing column. How to read what an SST shows you before it fails.
Read the essayJune 23, 2026
— 06 / How it starts
Most projects begin with a 30-minute call. You tell me the symptom or the goal, I tell you honestly whether I can help, what it would take, and what it would cost. No pitch, no obligation. If it's a fit, I send a written scope before any work begins.
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